Summary information and primary citation
- PDB-id
-
1xnr;
DSSR-derived features in text and
JSON formats; DNAproDB
- Class
- ribosome
- Method
- X-ray (3.1 Å)
- Summary
- Crystal structure of an inosine-cytosine wobble base
pair in the context of the decoding center
- Reference
-
Murphy FV, Ramakrishnan V (2004): "Structure
of a purine-purine wobble base pair in the decoding
center of the ribosome."
Nat.Struct.Mol.Biol., 11,
1251-1252. doi: 10.1038/nsmb866.
- Abstract
- Here we report the crystal structures of I.C and I.A
wobble base pairs in the context of the ribosomal decoding
center, clearly showing that the I.A base pair is of an
I(anti).A(anti) conformation, as predicted by Crick.
Additionally, the structures enable the observation of
changes in the anticodon to allow purine-purine base
pairing, the 'widest' base pair geometry allowed in the
wobble position.
