Summary information and primary citation
- PDB-id
-
1t2r;
DSSR-derived features in text and
JSON formats; DNAproDB
- Class
- nucleic acid binding protein-RNA
- Method
- NMR
- Summary
- Structural basis for 3' end recognition of nucleic
acids by the drosophila argonaute 2 paz domain
- Reference
-
Lingel A, Simon B, Izaurralde E, Sattler M (2004):
"Nucleic
acid 3'-end recognition by the Argonaute2 PAZ
domain." Nat.Struct.Mol.Biol.,
11, 576-577. doi: 10.1038/nsmb777.
- Abstract
- We describe the solution structures of the Argonaute2
PAZ domain bound to RNA and DNA oligonucleotides. The
structures reveal a unique mode of single-stranded nucleic
acid binding in which the two 3'-terminal nucleotides are
buried in a hydrophobic cleft. We propose that the PAZ
domain contributes to the specific recognition of siRNAs by
providing a binding pocket for their characteristic
two-nucleotide 3' overhangs.
