Summary information and primary citation
- PDB-id
-
1j5e;
DSSR-derived features in text and
JSON formats; DNAproDB
- Class
- ribosome
- Method
- X-ray (3.05 Å)
- Summary
- Structure of the thermus thermophilus 30s ribosomal
subunit
- Reference
-
Wimberly BT, Brodersen DE, Clemons Jr WM, Morgan-Warren
RJ, Carter AP, Vonrhein C, Hartsch T, Ramakrishnan V
(2000): "Structure
of the 30S ribosomal subunit." Nature,
407, 327-339. doi: 10.1038/35030006.
- Abstract
- Genetic information encoded in messenger RNA is
translated into protein by the ribosome, which is a large
nucleoprotein complex comprising two subunits, denoted 30S
and 50S in bacteria. Here we report the crystal structure
of the 30S subunit from Thermus thermophilus, refined to 3
A resolution. The final atomic model rationalizes over four
decades of biochemical data on the ribosome, and provides a
wealth of information about RNA and protein structure,
protein-RNA interactions and ribosome assembly. It is also
a structural basis for analysis of the functions of the 30S
subunit, such as decoding, and for understanding the action
of antibiotics. The structure will facilitate the
interpretation in molecular terms of lower resolution
structural data on several functional states of the
ribosome from electron microscopy and crystallography.
