Summary information and primary citation
- PDB-id
-
1i9f;
DSSR-derived features in text and
JSON formats; DNAproDB
- Class
- de-novo protein-RNA
- Method
- NMR
- Summary
- Structural characterization of the complex of the rev
response element RNA with a selected peptide
- Reference
-
Zhang Q, Harada K, Cho HS, Frankel AD, Wemmer DE (2001):
"Structural
characterization of the complex of the Rev response
element RNA with a selected peptide."
Chem.Biol., 8, 511-520. doi:
10.1016/S1074-5521(01)00027-8.
- Abstract
- Results: The binding of the RSG-1.2 peptide to the Rev
response element RNA was characterized using multinuclear,
multidimensional NMR. The RSG-1.2 peptide is shown to bind
with the N-terminal segment of the peptide along the major
groove in an extended conformation and turn preceding a
C-terminal helical segment, which crosses the RNA groove in
the region widened by the presence of purine-purine base
pairs. These features make the details of the bound state
rather different than that of the Rev peptide which targets
the same RNA sequence binding as a single helix along the
groove axis.
Conclusions: These studies further demonstrate the
versatility of arginine-rich peptides in recognition of
specific RNA elements and the lack of conserved structural
features in the bound state.
