SNAP annotations: PDB entry 1hnw

PDB-id

1hnw; DSSR-derived features in text and JSON formats; DNAproDB

Class

ribosome

Method

X-ray (3.4 Å)

Summary

Structure of the thermus thermophilus 30s ribosomal subunit in complex with tetracycline

Reference

Brodersen DE, Clemons Jr WM, Carter AP, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V (2000): "The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit." Cell(Cambridge,Mass.), 103, 1143-1154. doi: 10.1016/S0092-8674(00)00216-6.

Abstract

We have used the recently determined atomic structure of the 30S ribosomal subunit to determine the structures of its complexes with the antibiotics tetracycline, pactamycin, and hygromycin B. The antibiotics bind to discrete sites on the 30S subunit in a manner consistent with much but not all biochemical data. For each of these antibiotics, interactions with the 30S subunit suggest a mechanism for its effects on ribosome function.