Summary information and primary citation
- PDB-id
-
1hcq;
DSSR-derived features in text and
JSON formats; DNAproDB
- Class
- transcription-DNA
- Method
- X-ray (2.4 Å)
- Summary
- The crystal structure of the estrogen receptor
DNA-binding domain bound to DNA: how receptors discriminate
between their response elements
- Reference
-
Schwabe JW, Chapman L, Finch JT, Rhodes D (1993):
"The crystal
structure of the estrogen receptor DNA-binding domain
bound to DNA: how receptors discriminate between their
response elements." Cell(Cambridge,Mass.),
75, 567-578. doi: 10.1016/0092-8674(93)90390-C.
- Abstract
- The nuclear hormone receptors are a superfamily of
ligand-activated DNA-binding transcription factors. We have
determined the crystal structure (at 2.4 A) of the fully
specific complex between the DNA-binding domain from the
estrogen receptor and DNA. The protein binds as a
symmetrical dimer to its palindromic binding site
consisting of two 6 bp consensus half sites with three
intervening base pairs. This structure reveals how the
protein recognizes its own half site sequence rather than
that of the related glucocorticoid receptor, which differs
by only two base pairs. Since all nuclear hormone receptors
recognize one or the other of these two consensus half site
sequences, this recognition mechanism applies generally to
the whole receptor family.
