Summary information and primary citation
- PDB-id
-
1f8v;
DSSR-derived features in text and
JSON formats; DNAproDB
- Class
- virus-RNA
- Method
- X-ray (3.0 Å)
- Summary
- The structure of pariacoto virus reveals a dodecahedral
cage of duplex RNA
- Reference
-
Tang L, Johnson KN, Ball LA, Lin T, Yeager M, Johnson JE
(2001): "The
structure of pariacoto virus reveals a dodecahedral cage
of duplex RNA." Nat.Struct.Biol.,
8, 77-83. doi: 10.1038/83089.
- Abstract
- The 3.0 A resolution crystal structure of Pariacoto
virus (PaV) reveals extensive interactions between portions
of the viral RNA genome and the icosahedral capsid. Under
the protein shell of the T = 3 quasi equivalent capsid lies
a dodecahedral cage composed of RNA duplex that accounts
for approximately 35% of the single-stranded RNA genome.
The highly basic N-terminal regions (residues 7-54) of the
subunits, forming pentamers (A subunits) are clearly
visible in the density map and make numerous interactions
with the RNA cage. The C-terminal segments (residues
394-401) of the A subunits lie in channels near the quasi
three-fold axes. Electron cryo-microscopy and image
reconstruction of PaV particles clearly show the
dodecahedral RNA cage.
