Summary information and primary citation
- PDB-id
-
1ecr;
DSSR-derived features in text and
JSON formats; DNAproDB
- Class
- replication-DNA
- Method
- X-ray (2.7 Å)
- Summary
- Escherichia coli replication terminator protein (tus)
complexed with DNA
- Reference
-
Kamada K, Horiuchi T, Ohsumi K, Shimamoto N, Morikawa K
(1996): "Structure
of a replication-terminator protein complexed with
DNA." Nature, 383, 598-603.
doi: 10.1038/383598a0.
- Abstract
- The crystal structure of the Escherichia coli
replication-terminator protein (Tus) bound to terminus-site
(Ter) DNA has been determined at 2.7 A resolution. The Tus
protein folds into a previously undescribed architecture
divided into two domains by a central basic cleft. This
cleft accommodates locally deformed B-form Ter DNA and
makes extensive contacts with the major groove, mainly
through two interdomain beta-strands. The unusual
structural features of this complex may explain how the
replication fork is halted in only one direction.
