Summary information and primary citation
- PDB-id
-
1cdw;
DSSR-derived features in text and
JSON formats; DNAproDB
- Class
- transcription-DNA
- Method
- X-ray (1.9 Å)
- Summary
- Human tbp core domain complexed with DNA
- Reference
-
Nikolov DB, Chen H, Halay ED, Hoffman A, Roeder RG,
Burley SK (1996): "Crystal
structure of a human TATA box-binding protein/TATA
element complex." Proc.Natl.Acad.Sci.USA,
93, 4862-4867. doi: 10.1073/pnas.93.10.4862.
- Abstract
- The TATA box-binding protein (TBP) is required by all
three eukaryotic RNA polymerases for correct initiation of
transcription of ribosomal, messenger, small nuclear, and
transfer RNAs. The cocrystal structure of the
C-terminal/core region of human TBP complexed with the TATA
element of the adenovirus major late promoter has been
determined at 1.9 angstroms resolution. Structural and
functional analyses of the protein-DNA complex are
presented, with a detailed comparison to our 1.9-angstroms
resolution structure of Arabidopsis thaliana TBP2 bound to
the same TATA box.
