Summary information and primary citation
- PDB-id
-
1bl0;
DSSR-derived features in text and
JSON formats; DNAproDB
- Class
- transcription-DNA
- Method
- X-ray (2.3 Å)
- Summary
- Multiple antibiotic resistance protein (mara)-DNA
complex
- Reference
-
Rhee S, Martin RG, Rosner JL, Davies DR (1998): "A novel
DNA-binding motif in MarA: the first structure for an
AraC family transcriptional activator."
Proc.Natl.Acad.Sci.USA, 95,
10413-10418. doi: 10.1073/pnas.95.18.10413.
- Abstract
- A crystal structure for a member of the AraC
prokaryotic transcriptional activator family, MarA, in
complex with its cognate DNA-binding site is described.
MarA consists of two similar subdomains, each containing a
helix-turn-helix DNA-binding motif. The two recognition
helices of the motifs are inserted into adjacent major
groove segments on the same face of the DNA but are
separated by only 27 A thereby bending the DNA by
approximately 35 degrees. Extensive interactions between
the recognition helices and the DNA major groove provide
the sequence specificity.
