Summary information and primary citation
- PDB-id
-
1bg1;
DSSR-derived features in text and
JSON formats; DNAproDB
- Class
- transcription-DNA
- Method
- X-ray (2.25 Å)
- Summary
- Transcription factor stat3b-DNA complex
- Reference
-
Becker S, Groner B, Muller CW (1998): "Three-dimensional
structure of the Stat3beta homodimer bound to DNA."
Nature, 394, 145-151. doi:
10.1038/28101.
- Abstract
- STAT proteins are a family of eukaryotic transcription
factors that mediate the response to a large number of
cytokines and growth factors. Upon activation by
cell-surface receptors or their associated kinases, STAT
proteins dimerize, translocate to the nucleus and bind to
specific promoter sequences on their target genes. Here we
report the first crystal structure of a STAT protein bound
to its DNA recognition site at 2.25 A resolution. The
structure provides insight into the various steps by which
STAT proteins deliver a response signal directly from the
cell membrane to their target genes in the nucleus.
