Summary information and primary citation
- PDB-id
-
1awc;
DSSR-derived features in text and
JSON formats; DNAproDB
- Class
- transcription-DNA
- Method
- X-ray (2.15 Å)
- Summary
- Mouse gabp alpha-beta domain bound to DNA
- Reference
-
Batchelor AH, Piper DE, de la Brousse FC, McKnight SL,
Wolberger C (1998): "The
structure of GABPalpha/beta: an ETS domain- ankyrin
repeat heterodimer bound to DNA." Science,
279, 1037-1041. doi: 10.1126/science.279.5353.1037.
- Abstract
- GA-binding protein (GABP) is a transcriptional
regulator composed of two structurally dissimilar subunits.
The alpha subunit contains a DNA-binding domain that is a
member of the ETS family, whereas the beta subunit contains
a series of ankyrin repeats. The crystal structure of a
ternary complex containing a GABPalpha/beta ETS
domain-ankyrin repeat heterodimer bound to DNA was
determined at 2. 15 angstrom resolution. The structure
shows how an ETS domain protein can recruit a partner
protein using both the ETS domain and a carboxyl-terminal
extension and provides a view of an extensive
protein-protein interface formed by a set of ankyrin
repeats. The structure also reveals how the GABPalpha ETS
domain binds to its core GGA DNA-recognition motif.
