Summary information and primary citation
- PDB-id
-
1aoi;
DSSR-derived features in text and
JSON formats; DNAproDB
- Class
- DNA binding protein-DNA
- Method
- X-ray (2.8 Å)
- Summary
- Complex between nucleosome core particle
(h3,h4,h2a,h2b) and 146 bp long DNA fragment
- Reference
-
Luger K, Mader AW, Richmond RK, Sargent DF, Richmond TJ
(1997): "Crystal
structure of the nucleosome core particle at 2.8 A
resolution." Nature, 389,
251-260. doi: 10.1038/38444.
- Abstract
- The X-ray crystal structure of the nucleosome core
particle of chromatin shows in atomic detail how the
histone protein octamer is assembled and how 146 base pairs
of DNA are organized into a superhelix around it. Both
histone/histone and histone/DNA interactions depend on the
histone fold domains and additional, well ordered structure
elements extending from this motif. Histone amino-terminal
tails pass over and between the gyres of the DNA superhelix
to contact neighbouring particles. The lack of uniformity
between multiple histone/DNA-binding sites causes the DNA
to deviate from ideal superhelix geometry.
