Summary information and primary citation
- PDB-id
-
1a6y;
DSSR-derived features in text and
JSON formats; DNAproDB
- Class
- transcription-DNA
- Method
- X-ray (2.3 Å)
- Summary
- Reverba orphan nuclear receptor-DNA complex
- Reference
-
Zhao Q, Khorasanizadeh S, Miyoshi Y, Lazar MA, Rastinejad
F (1998): "Structural
elements of an orphan nuclear receptor-DNA complex."
Mol.Cell, 1, 849-861. doi:
10.1016/S1097-2765(00)80084-2.
- Abstract
- The nuclear hormone receptors form the largest known
family of transcription factors. The current notion of
receptor DNA discrimination, based solely on one major type
of hexameric half-site and a highly conserved 66-residue
core DNA-binding domain (DBD), does not adequately describe
how more than 150 nonsteroid receptors differentiate among
response elements. Here, we describe the 2.3 A crystal
structure of the DNA-binding region of the orphan receptor
RevErb arranged as a tandem homodimer on its optimal
response element. The structure reveals the presence of a
second major protein-DNA interface adjacent to the
classical one involving the half-sites. A sequence
comparison of orphan receptors suggests that unique
minor-groove interactions involving the receptor hinge
regions impart the necessary DNA and dimerization
specificity.
