SNAP annotations: PDB entry 10px

PDB-id

10px; DSSR-derived features in text and JSON formats; DNAproDB

Class

ribosome

Method

X-ray (2.45 Å)

Summary

Crystal structure of the wild-type thermus thermophilus 70s ribosome in complex with benzoxaborole derivative of azithromycin (azi-bb2), mrna, aminoacylated a-site phe-trnaphe, aminoacylated p-site fmet-trnamet, and deacylated e-site trnaphe at 2.45a resolution

Reference

Volynkina IA, Bortyazh MO, Chen C-W, Tereshchenkov AG, Karakchieva AO, Lukianov DA, Komarova ES, Tupikin AE, Skvortsov DA, Tevyashova AN, Tikhomirov AS, Tashlitsky VN, Kabilov MR, Shchekotikhin AE, Dontsova OA, Polikanov YS, Sergiev PV (2026): "Benzoxaborole-modified azithromycins inhibit translation without inducing ermC expression." Antimicrob.Agents Chemother., e0153925. doi: 10.1128/aac.01539-25.

Abstract