SNAP-annotated 5mC-DNA-protein interactions: PDB entry 9v36

PDB-id

9v36; DSSR-derived features in text and JSON formats; DNAproDB

Class

transferase

Method

cryo-EM (2.77 Å)

Summary

Human dnmt1 (aa 698-1616) bound to hemimethylated dsDNA and inhibitor dmi26

Reference

Li Z: "Human DNMT1 (aa 698-1616) bound to hemimethylated dsDNA and Inhibitor DMI26."

Abstract

 

• The contacts include paired nucleotides (mostly a G in Watson-Crick G-C pairing) and amino-acids within a 4.5-Å distance cutoff to base atoms of 5mC.
• The structure is oriented in the base reference frame of 5mC, allowing for easy comparison and direct superimposition between entries.
• The black sphere (•) denotes the 5-methyl carbon atom in 5mC.