SNAP-annotated 5mC-DNA-protein interactions: PDB entry 9m76

PDB-id

9m76; DSSR-derived features in text and JSON formats; DNAproDB

Class

DNA binding protein

Method

cryo-EM (4.1 Å)

Summary

Uhrf1 bound to a mononucleosome in its pre-active state, with the ring domain bound to the sra domain.

Reference

Naschberger A, Baradaran R, Sayed A, Fischle W: "The cryo-EM structure of human UHRF1 bound to mononucleosomes."

Abstract

 

• The contacts include paired nucleotides (mostly a G in Watson-Crick G-C pairing) and amino-acids within a 4.5-Å distance cutoff to base atoms of 5mC.
• The structure is oriented in the base reference frame of 5mC, allowing for easy comparison and direct superimposition between entries.
• The black sphere (•) denotes the 5-methyl carbon atom in 5mC.